Objective: Chemotherapy is one of the important adjuvant methods for the treatment of glioblastoma (GBM). and chemotherapy resistance is a clinical problem that neurooncologists need to solve urgently. It is reported that Saikosaponin D (SSD). an active component of Bupleurum chinense. https://www.tipsfromatypicalmom.com/product-category/fiesta-gothic-victorian/