The proliferation of specific lymphocytes is the central tenet of the clonal selection paradigm. Antigen recognition by T cells triggers a series of events that produces expanded clones of differentiated effector cells. TCR signaling events are detectable within seconds and minutes and are likely to continue for hours and days in vivo. https://www.roneverhart.com/Verragio-Paradiso-Round-Diamond-Engagement-Ring-Setting-0-55-CTW-p5464/